Nimesulide 100mg. + Paracetamol 325mg. (Bilayer) is a bilayer tablet formulation designed for the sustained release of both active ingredients, offering prolonged pain relief and anti-inflammatory effects. Nimesulide, a selective COX-2 inhibitor, targets inflammation and pain, making it effective for conditions like arthritis and musculoskeletal pain. Paracetamol, known for its analgesic and antipyretic properties, provides additional pain relief and helps in reducing fever. The bilayer design ensures that both drugs are released in a controlled manner, optimizing therapeutic effects over time while minimizing side effects. This combination is commonly used for the management of moderate pain, including post-operative pain, and other inflammatory conditions.